Cytogenetic risk stratification of 417 patients with chronic myelomonocytic leukemia from a single institution
نویسندگان
چکیده
منابع مشابه
Cytogenetic risk stratification in chronic myelomonocytic leukemia.
BACKGROUND The prognostic value of cytogenetic findings in chronic myelomonocytic leukemia is unclear. Our purpose was to evaluate the independent prognostic impact of cytogenetic abnormalities in a large series of patients with chronic myelomonocytic leukemia included in the database of the Spanish Registry of Myelodysplastic Syndromes. DESIGN AND METHODS We studied 414 patients with chronic...
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Clonal cytogenetic abnormalities are found in 20-30% of patients with chronic myelomonocytic leukemia (CMML), while gene mutations are present in >90% of cases. Patients with low risk cytogenetic features account for 80% of CMML cases and often fall into the low risk categories of CMML prognostic scoring systems, but the outcome differs considerably among them. We performed targeted deep sequen...
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CMML is a clonal malignant myeloid disorder sharing features of myelodysplastic syndromes and chronic myeloproliferative neoplasms. It is characterized by peripheral blood monocytosis, dysplastic features in at least 1 hematopoietic cell line and increased risk of progression to AML [1]. CMML has a male preponderance (1.5-3.0:1) [2]. The median age at diagnosis of CMML is about 70 years [3]. Th...
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Background: Acute Myeloid Leukemia (AML) with translocation (3,3) is a form of AML that may present de novo or may arise from a previous myelodysplastic syndrome. It is often associated with normal or elevated peripheral blood platelet count and increased bone marrow megakaryocytes with associated multi lineage dysplasia. A subset of patients present with hepatosplenomegaly while a few cases h...
متن کاملCytogenetic and molecular abnormalities in chronic myelomonocytic leukemia.
Chronic myelomonocytic leukemia (CMML) is a clonal stem cell disorder associated with peripheral blood monocytosis and an inherent tendency to transform to acute myeloid leukemia. CMML has overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms. Clonal cytogenetic changes are seen in ~30%, whereas gene mutations are seen in >90% of patients. Common cytogenetic abnorma...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2014
ISSN: 0361-8609
DOI: 10.1002/ajh.23751